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Caffeine in powder or liquid form can provide toxic levels of caffeine, the U.S. Food and Drug Administration has cautioned. Just one teaspoon of powdered caffeine is equivalent to about 28 cups of coffee. Such high levels of caffeine can cause serious health problems and possibly death.
Also, caffeine can pass into breast milk, so nursing mothers should closely monitor caffeine intake to make sure it is on the low side (1-2 cups per day). High intake of caffeine by nursing.
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The information on this page is current as of April 1 2020.
(c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used in cola-type beverages in accordance with good manufacturing practice.
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For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR).
Caffeinated 1 3 100

For the most up-to-date version of CFR Title 21, go to the Electronic Code of Federal Regulations (eCFR).
Caffeinated 1 3 100Caffeinated 1 3 1 +New SearchHelp | More About 21CFR 
[Code of Federal Regulations]
[Title 21, Volume 3]
[Revised as of April 1, 2020]
[CITE: 21CFR182.1180]

TITLE 21--FOOD AND DRUGS
CHAPTER I--FOOD AND DRUG ADMINISTRATION
DEPARTMENT OF HEALTH AND HUMAN SERVICES
SUBCHAPTER B - FOOD FOR HUMAN CONSUMPTION (CONTINUED)
Subpart B - Multiple Purpose GRAS Food Substances 
 Sec. 182.1180 Caffeine. 
(a) Product. Caffeine.
(b) Tolerance. 0.02 percent.
(c) Limitations, restrictions, or explanation. This substance is generally recognized as safe when used in cola-type beverages in accordance with good manufacturing practice.